ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney
نویسندگان
چکیده
منابع مشابه
ACE2 deficiency increases NADPH‐mediated oxidative stress in the kidney
Abstract Angiotensin-converting enzyme 2 (ACE2) is highly expressed in the kidney and hydrolyzes angiotensin II (Ang II) to Ang(1-7). Since Ang II is a strong activator of oxidative stress, we reasoned that ACE2 could be involved in the regulation of renal oxidative stress by governing the levels of Ang II. We, therefore, assessed levels of oxidative stress in kidney cortex of ACE2 knockout and...
متن کاملHigh-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage.
BACKGROUND Angiotensin II (AngII) contributes to salt-driven kidney damage. In this study, we aimed at investigating whether and how the renal damage associated with a high-salt diet could result from changes in the ratio between angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2). METHODS Forty-eight rats randomly allocated to three different dietary contents of sa...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2014
ISSN: 2051-817X
DOI: 10.1002/phy2.264